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The thiolation of pentafluorobenzene with disulfides by C–H, C–F bond activation and C–S bond formation

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Abstract

A metal-free thiolation reaction between pentafluorobenzene and disulfides by C–H, C–F bond activation and C–S bond formation is reported. Bisthiolated tetrafluorobenzene derivatives would be prepared in moderate to good yields from pentafluorobenzene and disulfides under mild conditions. A possible mechanism for the reaction was given.

Graphical abstract: The thiolation of pentafluorobenzene with disulfides by C–H, C–F bond activation and C–S bond formation

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Publication details

The article was received on 18 Nov 2017, accepted on 10 Jan 2018 and first published on 10 Jan 2018


Article type: Paper
DOI: 10.1039/C7OB02836A
Citation: Org. Biomol. Chem., 2018, Advance Article
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    The thiolation of pentafluorobenzene with disulfides by C–H, C–F bond activation and C–S bond formation

    Z. Liu, K. Ouyang and N. Yang, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C7OB02836A

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