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Total synthesis of five natural eremophilane-type sesquiterpenoids

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Abstract

The first total syntheses of five natural eremophilane-type sesquiterpenoids were achieved in 4–12 steps via a common synthetic intermediate. The syntheses feature a double Michael addition, Robinson annulation, α-enolization of an unsaturated ketone, and Pd-catalyzed Suzuki coupling reaction to install the side chain. This synthetic strategy could be easily extended to other eremophilane-type sesquiterpenoids with similar bicyclic skeletons.

Graphical abstract: Total synthesis of five natural eremophilane-type sesquiterpenoids

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Publication details

The article was received on 11 Nov 2017, accepted on 01 Jan 2018 and first published on 03 Jan 2018


Article type: Paper
DOI: 10.1039/C7OB02769A
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Total synthesis of five natural eremophilane-type sesquiterpenoids

    Z. Meng and B. Liu, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C7OB02769A

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