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A domino reaction of 3-chlorochromones with aminoheterocycles. Synthesis of pyrazolopyridines and benzofuropyridines and their optical and ecto-5′-nucleotidase inhibitory effects

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Abstract

A new and efficient domino reaction of 3-chlorochromones with electron-rich aminoheterocycles was developed which allows for a convenient synthesis of a variety of pyrazolo[3,4-b]pyridines, pyrrolo[2,3-b]pyridines, pyrido[2,3-d]pyrimidines and benzofuro[3,2-b]pyridines. The products exhibit strong fluorescence. In addition, they exhibit significant ecto-5′-nucleotidase inhibition properties and cytotoxic behavior.

Graphical abstract: A domino reaction of 3-chlorochromones with aminoheterocycles. Synthesis of pyrazolopyridines and benzofuropyridines and their optical and ecto-5′-nucleotidase inhibitory effects

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Publication details

The article was received on 07 Nov 2017, accepted on 22 Dec 2017 and first published on 22 Dec 2017


Article type: Paper
DOI: 10.1039/C7OB02729J
Citation: Org. Biomol. Chem., 2018, Advance Article
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    A domino reaction of 3-chlorochromones with aminoheterocycles. Synthesis of pyrazolopyridines and benzofuropyridines and their optical and ecto-5′-nucleotidase inhibitory effects

    M. Miliutina, J. Janke, S. Hassan, S. Zaib, J. Iqbal, J. Lecka, J. Sévigny, A. Villinger, A. Friedrich, S. Lochbrunner and P. Langer, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C7OB02729J

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