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Issue 15, 2018
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Catalytic asymmetric construction of spiropyrrolidines via 1,3-dipolar cycloaddition of azomethine ylides

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Abstract

Spirocyclic pyrrolidines are structural motifs frequently found in a wide variety of natural products, pharmaceuticals and biologically significant compounds. In the past few years, catalytic asymmetric 1,3-dipolar cycloaddition reactions of azomethine ylides have shown to be one of the most straightforward methods for the stereoselective preparation of diverse biologically important spiropyrrolidine heterocycles in high yields with excellent enantioselectivities under mild reaction conditions. In this review, we will discuss the recent major developments in the catalytic enantioselective synthesis of chiral spiropyrrolidine derivatives since 2009.

Graphical abstract: Catalytic asymmetric construction of spiropyrrolidines via 1,3-dipolar cycloaddition of azomethine ylides

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Publication details

The article was received on 01 Nov 2017, accepted on 10 Mar 2018 and first published on 14 Mar 2018


Article type: Review Article
DOI: 10.1039/C7OB02686B
Citation: Org. Biomol. Chem., 2018,16, 2591-2601
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    Catalytic asymmetric construction of spiropyrrolidines via 1,3-dipolar cycloaddition of azomethine ylides

    X. Fang and C. Wang, Org. Biomol. Chem., 2018, 16, 2591
    DOI: 10.1039/C7OB02686B

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