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Iodine promoted dual oxidative C (sp3) –H amination of 2-methyl-3-aryl quinazolin-4(3H)-ones: A facile route to 1,4-diarylimidazo [1,5-a]quinazoline-5(4H)-ones

Abstract

An efficient iodine promoted tandem oxidative condensation of benzyl amines and 2-methylquinazolin-4-(3H)-ones was developed to yield imidazo[1,5-a]quinazolin-5(4H)-ones via dual C(sp3)−H amination under metal free conditions in a greener way using molecular oxygen as terminal oxidant. This tandem transformation provides an efficient approach to construct various functionalized imidazo[1,5-a]quinazolin-5(4H)-ones in a straightforward manner via a sequential amination-oxidation-annulation-aromatisation.

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Publication details

The article was received on 31 Oct 2017, accepted on 07 Feb 2018 and first published on 07 Feb 2018


Article type: Paper
DOI: 10.1039/C7OB02677C
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
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    Iodine promoted dual oxidative C (sp3) –H amination of 2-methyl-3-aryl quinazolin-4(3H)-ones: A facile route to 1,4-diarylimidazo [1,5-a]quinazoline-5(4H)-ones

    K. Donthiboina, H. K. Namballa , S. P. Shaik, J. B. Nanubolu, N. Shankaraiah and A. Kamal, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C7OB02677C

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