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Issue 3, 2018
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An intramolecular tryptophan-condensation approach for peptide stapling

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Abstract

Stapled peptides are gaining tremendous interest as next-generation therapeutic agents to target protein–protein interactions. Herein, we report an intramolecular peptide stapling method which links two tryptophan residues at the C2 position of the indole moieties via acid-mediated condensation with an aldehyde.

Graphical abstract: An intramolecular tryptophan-condensation approach for peptide stapling

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Publication details

The article was received on 30 Oct 2017, accepted on 07 Dec 2017 and first published on 08 Dec 2017


Article type: Communication
DOI: 10.1039/C7OB02667F
Citation: Org. Biomol. Chem., 2018,16, 389-392
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    An intramolecular tryptophan-condensation approach for peptide stapling

    E. Y.-L. Hui, B. Rout, Y. S. Tan, C. S. Verma, K. Chan and C. W. Johannes, Org. Biomol. Chem., 2018, 16, 389
    DOI: 10.1039/C7OB02667F

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