Jump to main content
Jump to site search


Catalytic asymmetric enamine protonation reaction

Author affiliations

Abstract

Enantioselective protonation, delivery of a proton to a carbanion intermediate, is the most straightforward and fundamental method for the preparation of a chiral tertiary carbon stereocenter. Recent efforts for this objective have been realized through enamine catalysis, which has now become a prominent catalytic strategy enabling a range of fascinating chiral transformations. This review will summarize recent advances in the field of enantioselective enamine protonation for the synthesis of optically active carbonyl compounds. Dynamic kinetic resolutions of α-substituted carbonyl compounds through enamine intermediates will be discussed as well.

Graphical abstract: Catalytic asymmetric enamine protonation reaction

Back to tab navigation

Publication details

The article was received on 24 Oct 2017, accepted on 16 Dec 2017 and first published on 18 Dec 2017


Article type: Review Article
DOI: 10.1039/C7OB02615C
Citation: Org. Biomol. Chem., 2018, Advance Article
  •   Request permissions

    Catalytic asymmetric enamine protonation reaction

    N. Fu, L. Zhang and S. Luo, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C7OB02615C

Search articles by author

Spotlight

Advertisements