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[18F]ODIBO: a prosthetic group for bioorthogonal radiolabeling of macromolecules via strain-promoted alkyne–azide cycloaddition

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Abstract

A novel prosthetic group for the efficient radiolabeling of macromolecules has been developed. [18F]oxadibenzocyclooctyne ([18F]ODIBO) is synthesized in high radiochemical yield and applied for nearly quantitative conjugation to azide-tagged peptides and proteins at room temperature and low substrate concentrations. The resulting bioconjugates are chemically and radiochemically pure and free of toxic solvents and catalysts.

Graphical abstract: [18F]ODIBO: a prosthetic group for bioorthogonal radiolabeling of macromolecules via strain-promoted alkyne–azide cycloaddition

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Publication details

The article was received on 12 Oct 2017, accepted on 15 Nov 2017 and first published on 15 Nov 2017


Article type: Communication
DOI: 10.1039/C7OB02532G
Citation: Org. Biomol. Chem., 2018, Advance Article
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    [18F]ODIBO: a prosthetic group for bioorthogonal radiolabeling of macromolecules via strain-promoted alkyne–azide cycloaddition

    M. Boudjemeline, C. D. McNitt, T. A. Singleton, V. V. Popik and A. P. Kostikov, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C7OB02532G

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