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Rh(III)-Catalyzed ortho-C–H alkynylation of N-phenoxyacetamides with hypervalent iodine-alkyne reagents at room temperature

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Abstract

A Rh(III)-catalyzed C–H alkynylation of substituted N-phenoxyacetamides has been developed with the aid of hypervalent iodine-alkyne reagents. Complementary to the Sonogashira coupling reaction, this protocol provides an efficient and straightforward method to access aryl alkynes at room temperature. The multifunctional directing group is preserved which can be further employed for ortho-directed functionalizations to obtain additional new complex products.

Graphical abstract: Rh(iii)-Catalyzed ortho-C–H alkynylation of N-phenoxyacetamides with hypervalent iodine-alkyne reagents at room temperature

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Publication details

The article was received on 29 Sep 2017, accepted on 28 Nov 2017 and first published on 28 Nov 2017


Article type: Communication
DOI: 10.1039/C7OB02438J
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Rh(III)-Catalyzed ortho-C–H alkynylation of N-phenoxyacetamides with hypervalent iodine-alkyne reagents at room temperature

    S. Hu, L. Lu, T. Zhu, Q. Wu, Y. Chen, J. J. Li and J. Zhao, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C7OB02438J

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