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Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries

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Abstract

DNA encoded ligands are self-assembled into bivalent complexes and chemically ligated to link their identities. To demonstrate their potential as a combinatorial screening platform for avidity interactions, the optimal bivalent aptamer design (examplar ligands) for human alpha-thrombin is determined in a single round of selection and the DNA scaffold replaced with minimal impact on the final design.

Graphical abstract: Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries

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Publication details

The article was received on 24 Aug 2017, accepted on 30 Nov 2017 and first published on 07 Dec 2017


Article type: Communication
DOI: 10.1039/C7OB02119D
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries

    S. Matysiak, K. Hellmuth, A. H. El-Sagheer, A. Shivalingam, Y. Ariyurek, M. de Jong, M. J. Hollestelle, R. Out and T. Brown, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C7OB02119D

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