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DNA-Templated Nanoparticle Complex for Photothermal Imaging and Labeling of Cancer Cells

Abstract

In situ monitoring of photothermal (PT) effect at cellular level is of great importance for photothermal (PT) cancer treatment. Herein, we report a class of DNA-templated gold nanoparticle (GNP) – quantum dots (QDs) complex (GQC) for PT sensing in solution and in the cancer cells in vitro. Specifically, QD photoluminescence (PL) could be activated at elevated temperature with a wide thermo-responsive range between 45 °C and 70 °C, which fits the temperature threshold for effective cancer cell ablation. The general applicability of GQC for intracellular PT sensing is explored using three types of PT agents (gold nanorods (GNRs), gold nanostars (GNSs), and prussian blue nanoparticles (PBNPs)) with various PT performances. We show that the intracellular QD PL is gradually activated with increasing near-infrared (NIR) irradiation time, providing a good correlation with surrounding medium temperature for PT sensing. Moreover, we demonstrate that the GQC sensor could be used for specific photothermal labeling and imaging of cancer cells. The QD PL signal is retained in the cells post-treatment, thereby potentially enabling persistent photothermal labeling of cancer cells for post-treatment cell tracking and imaging-guided therapy evaluation.

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Supplementary files

Publication details

The article was accepted on 22 May 2018 and first published on 30 May 2018


Article type: Paper
DOI: 10.1039/C8NR03503B
Citation: Nanoscale, 2018, Accepted Manuscript
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    DNA-Templated Nanoparticle Complex for Photothermal Imaging and Labeling of Cancer Cells

    G. Wang, Z. Li, X. Luo, R. Yue, Y. Shen and N. Ma, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR03503B

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