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Large-Scale Synthesis of Uniform Lanthanide-Doped NaREF4 Upconversion/Downshifting Nanoprobes for Bioapplications

Abstract

Lanthanide (Ln3+)-doped NaREF4 (RE = rare earth) nanocrystals (NCs) are one of the most widely studied upconversion and downshifting luminescent nanoprobes. However, the size and optical performance of the Ln3+-doped NaREF4 NCs produced by the available lab-scale synthesis may vary from batch to batch, which inevitably limits their practical bioapplications. Herein, we report the synthesis of uniform Ln3+-doped NaREF4 NCs via a facile solid-liquid-thermal-decomposition (SLTD) method by directly employing NaHF2 powder as fluoride and sodium precursor. The proposed SLTD strategy is easy-to-perform, time-saving and cost-effective, making it ideal for scale-up syntheses. Particularly, over 63 g of β-NaGdF4:Yb,Er@NaYF4 core/shell NCs with narrow size variation (<7%) were synthesized via a one-pot reaction. By virtue of their superior upconversion and downshifting luminescence, we employed the synthesized core/shell nanoprobes for in vitro detection of prostate-specific antigen with a limit of detection down to 1.8 ng/mL, and for in vivo near-infrared imaging with a high signal-to-noise ratio of 12. These findings may pave the way for the commercialization of Ln3+-doped nanoprobes in bioassay kits for versatile clinical applications.

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Publication details

The article was received on 20 Apr 2018, accepted on 16 May 2018 and first published on 17 May 2018


Article type: Paper
DOI: 10.1039/C8NR03252A
Citation: Nanoscale, 2018, Accepted Manuscript
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    Large-Scale Synthesis of Uniform Lanthanide-Doped NaREF4 Upconversion/Downshifting Nanoprobes for Bioapplications

    W. You, D. Tu, W. Zheng, X. Shang, X. Song, S. Zhou, Y. Liu, R. Li and X. Chen, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR03252A

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