Jump to main content
Jump to site search


Three-dimensional Angiography Fused with CT/MRI for Multimodal Imaging of Nanoparticles Based on Ba4Yb3F17: Lu3+, Gd3+

Abstract

Designing nanosized multi-modality contrast agents for high-resolution imaging is challenging since most are only useful for single-mode imaging. In this work, we successfully synthesized biocompatible polyethylene glycol (PEG-) and L-glutamine (GLN-) modified nanoparticles Ba4Yb3F17:Lu3+, Gd3+ nanoparticles (LNPs@PEG@GLN) that can be employed as a multi-modality contrast agent. Fluorescence dye-modified LNPs@PEG@GLN nanoparticles can be used for computed tomography (CT), magnetic resonance imaging (MRI), and fluorescence imaging (FI). They display high X-ray absorption, outstanding T2-weighted imaging capability, and good fluorescence uptake. Furthermore, LNPs@PEG@GLN enhance contrast efficiencies for different imaging modalities in vivo. Interestingly, LNPs@PEG@GLN are a promising agent for CT angiography. These nanoparticles could be a promising contrast agent for multi-modality imaging and diagnosing vascular diseases.

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Apr 2018, accepted on 02 Jun 2018 and first published on 13 Jun 2018


Article type: Paper
DOI: 10.1039/C8NR03054E
Citation: Nanoscale, 2018, Accepted Manuscript
  •   Request permissions

    Three-dimensional Angiography Fused with CT/MRI for Multimodal Imaging of Nanoparticles Based on Ba4Yb3F17: Lu3+, Gd3+

    S. Ma, J. Zhang, S. Xia, W. Yin, Y. Qin, R. Lei, J. kong, L. Mei, J. Li, G. Xing and G. li, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR03054E

Search articles by author

Spotlight

Advertisements