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Issue 28, 2018
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Three-dimensional angiography fused with CT/MRI for multimodal imaging of nanoparticles based on Ba4Yb3F17:Lu3+,Gd3+

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Abstract

Designing nanosized multi-modality contrast agents for high-resolution imaging is challenging since most agents are only useful for single-mode imaging. In this work, we successfully synthesized biocompatible polyethylene glycol (PEG-) and L-glutamine (GLN-) modified Ba4Yb3F17:Lu3+,Gd3+ nanoparticles (LNPs@PEG@GLN) that can be employed as a multi-modality contrast agent. Fluorescence dye-modified LNPs@PEG@GLN nanoparticles can be used for computed tomography (CT), magnetic resonance imaging (MRI), and fluorescence imaging (FI). They display high X-ray absorption, outstanding T2-weighted imaging capability, and good fluorescence uptake. Furthermore, LNPs@PEG@GLN enhances contrast efficiencies for different imaging modalities in vivo. Interestingly, LNPs@PEG@GLN is a promising agent for CT angiography. These nanoparticles could be a promising contrast agent for multi-modality imaging and diagnosing vascular diseases.

Graphical abstract: Three-dimensional angiography fused with CT/MRI for multimodal imaging of nanoparticles based on Ba4Yb3F17:Lu3+,Gd3+

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Publication details

The article was received on 15 Apr 2018, accepted on 02 Jun 2018 and first published on 13 Jun 2018


Article type: Paper
DOI: 10.1039/C8NR03054E
Citation: Nanoscale, 2018,10, 13402-13409
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    Three-dimensional angiography fused with CT/MRI for multimodal imaging of nanoparticles based on Ba4Yb3F17:Lu3+,Gd3+

    S. Ma, J. Zhang, S. Xia, W. Yin, Y. Qin, R. Lei, J. Kong, L. Mei, J. Li, G. Xin and G. Li, Nanoscale, 2018, 10, 13402
    DOI: 10.1039/C8NR03054E

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