Jump to main content
Jump to site search


PEGylated Titanate Nanosheets: Hydrophilic Monolayers with a Superior Capacity for Selective Isolation of Immunoglobulin G

Abstract

A novel organic-inorganic hybrid were prepared by anchoring (3-aminopropyl)triethoxysilane (APTES) on the surface of monolayer titanate nanosheets and subsequent modification with hydrophilic polyethylene glycol (PEG). The PEGylated hydrophilic monolayer titanate nanosheets were abbreviated as PEG-APTES-TiNSs, they exhibit a lateral dimension of dozens of nanometers and a thickness of ca. 1.9 nm. PEGylation of the titanate nanosheets significantly improved their selectivity toward the adsorption of glycoprotein through strong hydrophilic interaction, providing an adsorption capacity of 2540.9 mg/g for immunoglobulin G (IgG). The retained IgG is readily collected with a recovery rate of 83.4% with 0.5% (m/v) ammonium hydroxide (NH4OH) as the stripping reagent. PEG-APTES-TiNSs are applied for the selective adsorption of IgG from human serum, which is further confirmed by SDS-PAGE assay.

Back to tab navigation

Supplementary files

Publication details

The article was received on 13 Apr 2018, accepted on 30 May 2018 and first published on 01 Jun 2018


Article type: Paper
DOI: 10.1039/C8NR02995D
Citation: Nanoscale, 2018, Accepted Manuscript
  •   Request permissions

    PEGylated Titanate Nanosheets: Hydrophilic Monolayers with a Superior Capacity for Selective Isolation of Immunoglobulin G

    P. Guo, D. Zhang, Z. Guo, X. Wang, M. Wang, M. Chen and J. Wang, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR02995D

Search articles by author

Spotlight

Advertisements