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Issue 26, 2018
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PEGylated titanate nanosheets: hydrophilic monolayers with a superior capacity for the selective isolation of immunoglobulin G

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Abstract

A novel organic–inorganic hybrid was prepared by anchoring (3-aminopropyl)triethoxysilane (APTES) on the surface of monolayer titanate nanosheets and subsequent modification with hydrophilic polyethylene glycol (PEG). The PEGylated hydrophilic monolayer titanate nanosheets were abbreviated as PEG–APTES–TiNSs, and they exhibit a lateral dimension of dozens of nanometers and a thickness of ca. 1.9 nm. PEGylation of the titanate nanosheets significantly improved their selectivity toward the adsorption of glycoproteins through strong hydrophilic interaction, providing an adsorption capacity of 2540.9 mg g−1 for immunoglobulin G (IgG). The retained IgG is readily collected at a recovery rate of 83.4% with 0.5% (m/v) ammonium hydroxide (NH4OH) as the stripping reagent. PEG–APTES–TiNSs are applied for the selective adsorption of IgG from human serum, which is further confirmed by SDS-PAGE assay.

Graphical abstract: PEGylated titanate nanosheets: hydrophilic monolayers with a superior capacity for the selective isolation of immunoglobulin G

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Publication details

The article was received on 13 Apr 2018, accepted on 30 May 2018 and first published on 01 Jun 2018


Article type: Paper
DOI: 10.1039/C8NR02995D
Citation: Nanoscale, 2018,10, 12535-12542
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    PEGylated titanate nanosheets: hydrophilic monolayers with a superior capacity for the selective isolation of immunoglobulin G

    P. Guo, D. Zhang, Z. Guo, X. Wang, M. Wang, M. Chen and J. Wang, Nanoscale, 2018, 10, 12535
    DOI: 10.1039/C8NR02995D

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