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A Facile Method for Preparation of Uniform Polymeric Vesicles with Tunable Size

Abstract

Vesicle size and size uniformity determine whether the vesicle can realize its full potential on a wide range of biological and biomedical applications. Herein, we reported a simple yet general cosolvent method to directly prepare uniform polymeric vesicles with tunable size ranging from 100 nm to 150 nm formed from the amphiphilic diblock copolymer poly(4-vinylpyridine)-block-polystyrene (P4VP77-b-PS318). The uniform polymeric vesicles can be easily obtained by adding plenty of selective solvent only once into polymer solution and then resting over night. It is found that the uniform vesicles are formed with a fixed size. There is no further fusion between vesicles. The PDI of the vesicles measured by DLS can be as lower as 0.03. Moreover, the size of these uniform vesicles can be controlled by the content of selective solvent. The higher the content of selective solvent is, the smaller the vesicles form. Monte Carlo simulation was also performed in this study. The simulation results indicated that the vesicles size indeed decreases with an increase in the content of selective solvent. Two reasons leading to the decrease in vesicle size are elucidated. In addition, the simulations reveal that the size uniformity of the vesicle are essentially determined by the interactive enthalpy of the system.

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Publication details

The article was accepted on 06 May 2018 and first published on 07 May 2018


Article type: Paper
DOI: 10.1039/C8NR02901F
Citation: Nanoscale, 2018, Accepted Manuscript
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    A Facile Method for Preparation of Uniform Polymeric Vesicles with Tunable Size

    M. Wu, Y. Wang, Y. Han, J. Cui and W. Jiang, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR02901F

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