Jump to main content
Jump to site search


Synergistic Combination Chemotherapy of Carrier-free Celastrol and Doxorubicin Nanocrystals for Overcoming Drug Resistance

Abstract

A key challenge of chemotherapy in clinic is multidrug resistance (MDR), which mainly arise from drug efflux induced tumor cell survival. It is thus necessary to provide biocompatible chemotherapeutics to improve drug accumulation in MDR cells. Herein, two clinical small molecular drugs of celastrol (CST) and doxorubicin (DOX) are self-assembled into carrier-free and biocompatible nanoparticles (CST/DOX NPs) with a simple and green precipitation method, for synergistic combination chemotherapy in overcoming DOX resistance. Spherical CST/DOX NPs can improve the water-solubility of CST, reduce the dosage of DOX, and therefore obviously enhance cellular drug accumulation via activating Heat shock factor 1 (HSF-1) and inhibiting NF-κB to depress P-gp expression, which result in apoptosis and autophagy of DOX resistant cells through ROS/JNK signaling pathway. And finally, synergistic combination chemotherapy was attained in both MCF-7/MDR cells and 3D Multicellular tumor spheroids. CST/DOX NPs provide an alternative for overcoming drug resistance in future clinic applications.

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Apr 2018, accepted on 12 Jun 2018 and first published on 12 Jun 2018


Article type: Paper
DOI: 10.1039/C8NR02700E
Citation: Nanoscale, 2018, Accepted Manuscript
  •   Request permissions

    Synergistic Combination Chemotherapy of Carrier-free Celastrol and Doxorubicin Nanocrystals for Overcoming Drug Resistance

    Y. Xiao, J. Liu, M. Guo, H. Zhou, J. Jin, J. Liu, Y. Liu, Z. Zhang and C. Chen, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR02700E

Search articles by author

Spotlight

Advertisements