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Diketopyrrolopyrrole-Based Carbon Dots for Photodynamic Therapy

Abstract

Developing a simple and straightforward strategy to synthesize multifunctional carbon dots for photodynamic therapy (PDT) was an emerging focus. In this work, a diketopyrrolopyrrole-based fluorescent carbon dots (DPP CDs) were designed and synthesized through a facile one-pot hydrothermal method by using diketopyrrolopyrrole (DPP) and chitosan (CTS) as raw materials. DPP CDs not only maintained the ability of DPP to generate singlet oxygen (1O2) but also has excellent hydrophilic properties and outstanding biocompatibility. In vitro and in vivo experiments demonstrated that DPP CDs greatly inhibited tumor cells growth under the laser irradiation (540 nm). This study highlights the potential of the rational design of CDs for efficient cancer therapy.

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Supplementary files

Publication details

The article was received on 02 Apr 2018, accepted on 10 May 2018 and first published on 11 May 2018


Article type: Paper
DOI: 10.1039/C8NR02643B
Citation: Nanoscale, 2018, Accepted Manuscript
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    Diketopyrrolopyrrole-Based Carbon Dots for Photodynamic Therapy

    H. He, X. Zheng, S. Liu, M. Zheng, Z. Xie, Y. Wang, M. Yu and X. Shuai, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR02643B

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