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A theranostic nanoplatform: magneto-gold@fluorescence polymer nanoparticles for tumor targeting T1&T2-MRI/CT/NIR fluorescence imaging and induction of genuine autophagy mediated chemotherapy

Abstract

Multifunctional nanoparticles, bearing with low toxicity and tumor targeting, coupled with multifunctional diagnostic imaging and enhance treatment efficacy, have drawn tremendous attentions due to their enormous potential for medical applications. Herein, we report a new kind of biocompatible and tumor-targeting magneto-gold@fluorescent polymer nanoparticles (MGFs-LyP-1), which is based on ultra-small magneto-gold (Fe3O4-Au) nanoparticles and NIR emissive fluorescent polymers by solvent-mediated method. This kind of nanoparticles could be taken up efficiently and simultaneously serve for in vivo tumor targeting T1&T2-MRI/CT/near infrared (NIR) fluorescence bioimaging. Furthermore, the nanoparticles exhibit small size, higher tumor targeting accumulation, excellent cytocompatibility for long-term tracking, and no disturbing cell proliferation and differentiation. Moreover, clear and convincing evidence proves that as-synthesized MGFs-LyP-1 could elicit genuine autophagy via inducing autophagosome formation, which offers a definite synergistic effect for enhance the cancer therapy with doxorubicin (DOX) at a nontoxic concentration through enhancement of the autophagy flux. Meanwhile, the as-prepared nanoparticles could be rapidly cleared from mice without any obvious organ impairment. The results indeed reveal a promising perspective of MGFs-LyP-1 contrast agent with low toxicity and high efficience for the promising application for biomedicine.

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Supplementary files

Publication details

The article was received on 24 Mar 2018, accepted on 06 May 2018 and first published on 11 May 2018


Article type: Paper
DOI: 10.1039/C8NR02429D
Citation: Nanoscale, 2018, Accepted Manuscript
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    A theranostic nanoplatform: magneto-gold@fluorescence polymer nanoparticles for tumor targeting T1&T2-MRI/CT/NIR fluorescence imaging and induction of genuine autophagy mediated chemotherapy

    G. Wang, K. Qian and X. Mei, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR02429D

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