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Proteins as Supramolecular Hosts for C60: A True Solution of C60 in Water

Abstract

Hybrid systems have great potential for a wide range of applications in chemistry, physics and materials science. Conjugation of a biosystem to a molecular material can tune the properties of the components or make new ones arise. As a workhorse, here we take C60@lysozyme hybrid. We show that lysozyme recognizes and disperses fullerene in water. AFM, Cryo-TEM and high resolution X-ray powder diffraction show that the C60 dispersion is monomolecular. The adduct is biocompatible, stable in physiological and technologically-relevant environments, and easily storable. Hybridization with lysozyme preserves the electrochemical properties of C60. EPR spin-trapping experiments show that the C60@lysozyme hybrid produces ROS following both the type I and type II mechanisms. Due to the shielding effect of the protein, the adduct generates significant amounts of 1O2 also in aqueous solution. In the case of the type II mechanism, the protein residues provide the electron and the hybrid does not require addition of external electron donors. The preparation and the properties of C60@lysozyme are general and can be expected to be similar in other C60@protein systems. It is envisaged that the properties of the C60@protein hybrids will pave the way for a host of applications in nanomedicine, nanotechnology, and photocatalysis.

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Publication details

The article was received on 17 Mar 2018, accepted on 01 May 2018 and first published on 01 May 2018


Article type: Paper
DOI: 10.1039/C8NR02220H
Citation: Nanoscale, 2018, Accepted Manuscript
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    Proteins as Supramolecular Hosts for C60: A True Solution of C60 in Water

    M. Di Giosia, P. Bomans, A. Bottoni, A. Cantelli, G. Falini, P. Franchi, G. Guarracino, H. Friedrich, M. Lucarini, F. Paolucci, S. Rapino, N. Sommerdijk, A. Soldà, F. Valle, F. Zerbetto and M. Calvaresi, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR02220H

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