Jump to main content
Jump to site search

Issue 22, 2018
Previous Article Next Article

Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor

Author affiliations

Abstract

A synthetic nanoreceptor, cucurbit[7]uril (CB[7]), fully encapsulated pentylenetetrazol (PTZ), a seizure-inducing model drug. As a consequence of the encapsulation, the development of PTZ induced convulsion behaviors in both larval zebrafish and mouse models were dramatically alleviated, suggesting that CB[7] holds great neuroprotection potential against neurotoxic drugs for clinical applications.

Graphical abstract: Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Mar 2018, accepted on 13 Apr 2018 and first published on 13 Apr 2018


Article type: Communication
DOI: 10.1039/C8NR02041H
Citation: Nanoscale, 2018,10, 10333-10336
  •   Request permissions

    Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor

    Q. Huang, K. I. Kuok, X. Zhang, L. Yue, S. M. Y. Lee, J. Zhang and R. Wang, Nanoscale, 2018, 10, 10333
    DOI: 10.1039/C8NR02041H

Search articles by author

Spotlight

Advertisements