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Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor

Abstract

A synthetic nanoreceptor, cucurbit[7]uril (CB[7]), fully encapsulated pentylenetetrazol (PTZ), a seizure-inducing model drug. As a consequence of the encapsulation, the development of PTZ induced convulsion behaviors in both larval zebrafish and mouse models were dramatically alleviated, suggesting that CB[7] holds great neuroprotection potential against neurotoxic drugs for clinical applications.

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Publication details

The article was accepted on 13 Apr 2018 and first published on 13 Apr 2018


Article type: Communication
DOI: 10.1039/C8NR02041H
Citation: Nanoscale, 2018, Accepted Manuscript
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    Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor

    Q. Huang, K. I. Kuok, X. Zhang, L. Yue, S. M. Lee, J. Zhang and R. Wang, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR02041H

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