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Gd-DTPA Coupled Ag2Se Quantum Dots for Dual-Modality Magnetic Resonance Imaging and Fluorescence Imaging in the Second Near-Infrared Window

Abstract

Near-infrared (NIR) fluorescent quantum dots (QDs) are ideal platforms to fabricate multifunctional contrast agents for multimodal imaging. Herein, the second near-infrared window fluorescent (NIR-II) Ag2Se QDs were coupled with Gd-DTPA for dual-modality T1-weighted magnetic resonance (MR) imaging and fluorescence imaging. In vitro experiments suggested that the prepared Ag2Se-Gd QDs exhibited low cytotoxicity, remarkable T1-weighted MR imaging and fluorescence imaging contrast properties. In vivo experiment results displayed that Ag2Se-Gd QDs were favorite contrast agents for dual-modality T1-weighted MR imaging and fluorescence imaging with high spatial resolution. Moreover, excellent temporal resolution and high tissue penetration depth were also achieved by fluorescence imaging. These results indicated the potential of Ag2Se-Gd QDs as multifunctional contrast agents for multimodal imaging in clinical diagnosis and research.

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Publication details

The article was received on 10 Mar 2018, accepted on 07 May 2018 and first published on 15 May 2018


Article type: Paper
DOI: 10.1039/C8NR02017E
Citation: Nanoscale, 2018, Accepted Manuscript
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    Gd-DTPA Coupled Ag2Se Quantum Dots for Dual-Modality Magnetic Resonance Imaging and Fluorescence Imaging in the Second Near-Infrared Window

    J. Ma, M. Yu, Z. Zhang, W. Cai, Z. Zhang, H. Zhu, Q. Cheng, Z. Tian and D. Pang, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR02017E

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