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Carbon coated core-shell multifunctional fluorescent SPIONs

Abstract

Due to unique magnetic property, multiple surface functionality and biocompatibility, superparamagnetic iron oxide nanoparticles (SPIONs) show very promising characteristics as magnetic resonance (MR) contrast agent in biomedical applications. However, lack of fluorescence in SPIONs make them inappropriate for multimodal bioimaging. SPIONs with surface functionalized either by organic fluorescent molecule or semiconductor quantum dots (QDs) have been reported as bioimaging probe but subsequent deterioration of the fluorescent dyes due to low photostability and quick photobleaching practically limits their long term application. In addition, QDs are found to be toxic in nature. Here, we present a novel one step method to synthesize nontoxic carbon coated highly photostable core-shell magnetic and fluorescent SPIONs with a long-lasting fluorescence property alongside superior magnetic resonance (MR) imaging ability. Apart from the highly comparable superparamagnetic properties of the SPIONs, the optical response of the material is much better than the commonly used Rhodamine or cyanine dyes.

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Supplementary files

Publication details

The article was received on 08 Mar 2018, accepted on 06 May 2018 and first published on 07 May 2018


Article type: Communication
DOI: 10.1039/C8NR01941J
Citation: Nanoscale, 2018, Accepted Manuscript
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    Carbon coated core-shell multifunctional fluorescent SPIONs

    A. Tiwari, N. C. VERMA, A. Singh, C. K. Nandi and J. K. Randhawa, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR01941J

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