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Deciphering the role of substrate stiffness in enhancing the internalization efficiency of plasmid DNA in stem cells using lipid-based nanocarriers

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Abstract

This study investigates the role of substrate stiffness in the non-viral transfection of human adipose-derived stem cells (hASCs) with the aim to maximize the hASC expression of vascular endothelial growth factor (VEGF). The results confirm the direct effect of substrate stiffness in regulating cytoskeletal remodeling and corresponding plasmid internalization.

Graphical abstract: Deciphering the role of substrate stiffness in enhancing the internalization efficiency of plasmid DNA in stem cells using lipid-based nanocarriers

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Publication details

The article was received on 22 Feb 2018, accepted on 05 Apr 2018 and first published on 06 Apr 2018


Article type: Communication
DOI: 10.1039/C8NR01516C
Citation: Nanoscale, 2018, Advance Article
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    Deciphering the role of substrate stiffness in enhancing the internalization efficiency of plasmid DNA in stem cells using lipid-based nanocarriers

    S. Modaresi, S. Pacelli, J. Whitlow and A. Paul, Nanoscale, 2018, Advance Article , DOI: 10.1039/C8NR01516C

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