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Carbon nanotubes (CNTs) based advanced dermal therapeutics: Current trends and future potential

Abstract

The search for some effective and non-invasive delivery modules to transport the therapeutic molecules across skin has led to the discovery of a number of nanocarriers (viz: liposomes, ethosomes, dendrimers, etc.) in last few decades. However, available literature suggests that these delivery modules are facing several issues including poor stability, low encapsulation efficiency, and scale-up hurdles. Recently carbon nanotubes (CNTs) emerged as a versatile tool to deliver the therapeutics across the skin. Superior stability, high loading capacity, well-developed synthesis protocol as well as ease of scale-up are some of the reason for growing interest in CNTs. CNTs have a unique physical architect, a large surface area with unique surface chemistry that can be tailored for vivid biomedical applications. CNTs have been thus largely engaged in the development of transdermal systems such as tuneable hydrogels, programmable nonporous membranes, electroresponsive skin modalities, protein channel mimetic platforms, reverse iontophoresis, microneedles, and dermal buckypapers. In addition, CNTs were also employed in the development of RNA interference (RNAi) based therapeutics for correcting the defective dermal genes. This review expounds the state-of-art synthesis methodologies, skin penetration mechanism, drug liberation profile, loading potential, characterization techniques, transdermal applications along with a summary on patent/regulatory status and future scope of CNT based skin therapeutics.

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Publication details

The article was received on 16 Feb 2018, accepted on 07 Apr 2018 and first published on 09 Apr 2018


Article type: Review Article
DOI: 10.1039/C8NR01383G
Citation: Nanoscale, 2018, Accepted Manuscript
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    Carbon nanotubes (CNTs) based advanced dermal therapeutics: Current trends and future potential

    K. Kuche, R. Maheshwari, V. Tambe, K. K. Mak, H. Jogi, N. Raval, M. R. Pichika and R. K. Tekade, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR01383G

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