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Ultrasmall Endogenous Biopolymer Nanoparticles for Magnetic Resonance /Photoacoustic Dual-Modal Imaging-Guided Photothermal Therapy

Abstract

Multi-modal imaging-guided photothermal therapy (PTT) has arouse extensive attention in biomedical research recently because it can provide more comprehensive information for accurate diagnosis and treatment. In this research, the manganese ions chelated endogenous biopolymer melanin nanoparticles were successfully prepared for magnetic resonance (MR) /photoacoustic (PA) dual-modal imaging-guided PTT. The obtained nanoparticles with ultrasmall size of about 3.2 nm exhibited negligible cytotoxicity, high relaxivity for MRI, excellent photothermal effect and PA activity. Moreover, in vivo MRI and PAI results all demonstrated that the nanoparticles began to diffuse in the blood after intratumorally injection into tumor-bearing mice and could spread throughout the whole tumor region at 3 h, indicating the optimal treatment time. The subsequent photothermal therapy of cancer in vivo was carried out and the result showed that tumor growth could be effectively inhibited without inducing any observed side effects. Besides, melanin as an endogenous biopolymer has native biocompatibility and biodegradability, and it can be excreted through both renal and hepatobiliary pathways after treatment. Therefore, the melanin-Mn nanoparticles may assist in better indicating the optimal treatment time, monitoring the therapeutic process and enhancing the therapeutic effect, showed great clinical translation potential for cancer diagnosis and therapy.

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Publication details

The article was received on 09 Feb 2018, accepted on 26 Apr 2018 and first published on 01 May 2018


Article type: Paper
DOI: 10.1039/C8NR01215F
Citation: Nanoscale, 2018, Accepted Manuscript
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    Ultrasmall Endogenous Biopolymer Nanoparticles for Magnetic Resonance /Photoacoustic Dual-Modal Imaging-Guided Photothermal Therapy

    J. Sun, W. Xu, L. Li, B. Fan, X. Peng, B. Qu, L. Wang, T. Li, S. Li and R. Zhang, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR01215F

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