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Aptamer-based, multifunctional ligand-modified UCNPs for targeted PDT and bioimaging

Abstract

We designed an aptamer-based multifunctional ligand which, upon conjugation to the surface of upconversion nanoparticles (UCNPs), could realize phase transfer, covalent photosensitizer (PS) loading, and cancer cell targeting in one simple step. The as-built PDT nanodrug is selectively internalized into cancer cells and exhibits highly efficient and selective cytotoxicity.

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Supplementary files

Publication details

The article was received on 06 Feb 2018, accepted on 26 Apr 2018 and first published on 03 May 2018


Article type: Paper
DOI: 10.1039/C8NR01096J
Citation: Nanoscale, 2018, Accepted Manuscript
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    Aptamer-based, multifunctional ligand-modified UCNPs for targeted PDT and bioimaging

    W. Hou, Y. Liu, Y. Jiang, Y. Wu, C. Cui, Y. Wang, L. Zhang, I. Teng and W. Tan, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR01096J

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