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Construction of dual-functional polymer nanomaterials with near-infrared fluorescence imaging and polymer prodrug by RAFT mediated aqueous dispersion polymerization

Abstract

The performance of functional polymer nanomaterials is the hotspot and focus of polymer science. We devoted ourselves to investigating polymer nanomaterials based on near-infrared (NIR) fluorescence imaging and polymer prodrug in this work. Aza-boron dipyrromethene (BODIPY) is an important organic dye, characteristic of environmental resistance, light resistance, high molar extinction coefficient and fluorescence quantum yield. We incorporate it into our target monomer, which can be polymerized without changing its parent structure in polar solvent and copolymerized with water-soluble monomer to improve the solubility of the dye in aqueous solution. At the same time, the hydrophobic drug camptothecin (CPT) was designed as a prodrug monomer, and the polymeric nanoparticles with NIR fluorescence imaging and prodrug were synthesized in situ in reversible addition-fragmentation chain transfer (RAFT)-mediated aqueous dispersion polymerization. The dynamic light scattering (DLS) and transmission electron microscopy (TEM) manifested the final uniform size of the dual-functional polymeric nanoparticles morphology. The dual-functional polymeric nanoparticles had a strong absorption and emission signal in the NIR region (> 650 nm) based on fluorescence tests. In consideration of the long-term biological toxicity, confocal laser scanning microscopy (CLSM) results indicated the dual-functional nanoparticles with controlled drug content exhibited effective capability of killing HeLa cells. In addition, In vivo imaging of the dual-functional nanoparticles was observed in real time and the fluorescent signals clearly demonstrated the dynamic process of prodrug transfer.

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Publication details

The article was received on 01 Feb 2018, accepted on 05 May 2018 and first published on 09 May 2018


Article type: Paper
DOI: 10.1039/C8NR00930A
Citation: Nanoscale, 2018, Accepted Manuscript
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    Construction of dual-functional polymer nanomaterials with near-infrared fluorescence imaging and polymer prodrug by RAFT mediated aqueous dispersion polymerization

    C. Tian, J. Niu, X. Wei, Y. Xu, L. Zhang, Z. Cheng and X. Zhu, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR00930A

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