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Size-dependent endocytosis and a dynamic-release mode of nanoparticles

Abstract

Polymeric nanopaticles for drug delivery are attracting broad concerns along with the rapid development of bio-medical and healthcare research. Here, we prepared a series of nanocapsules by electrostatic precipitation of chitosan and lecithin emulsion. These nanocapsules have controlled diameters (~ 25-200 nm) that only slightly changed after several lyophilization-dissolving circles, suggesting their excellent stability for long-term storage. In cell experiments, these nanocapsules obviously reduced the cytotoxicity of encapsulated small molecules, and clearly showed the size-dependent endocytosis. In a dynamic release mode mimicking the in vivo circulatory system, the nanocapsules demonstrated superiority over micelles as drug carriers due to their stable structures. To the best of our knowledge, this is the first dynamic mode to evaluate the drug-release bahaviour, which might open a new way to study release profile of other potential drug carriers.

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Publication details

The article was received on 30 Jan 2018, accepted on 13 Apr 2018 and first published on 17 Apr 2018


Article type: Paper
DOI: 10.1039/C8NR00830B
Citation: Nanoscale, 2018, Accepted Manuscript
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    Size-dependent endocytosis and a dynamic-release mode of nanoparticles

    R. Pan, G. Liu, Y. Li, Y. Wei, S. Li and L. Tao, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR00830B

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