Jump to main content
Jump to site search

Issue 14, 2018
Previous Article Next Article

Mesoporous silica nanoparticles engineered for ultrasound-induced uptake by cancer cells

Author affiliations

Abstract

A novel smart hierarchical ultrasound-responsive mesoporous silica nanocarrier for cancer therapy is presented here. This dynamic nanosystem has been designed to display different surface characteristics during its journey towards tumor cells. Initially, the anticancer-loaded nanocarriers are shielded with a polyethylene glycol layer. Upon exposure to high frequency ultrasound, the polymer shell detaches from the nanoparticles, exposing a positively charged surface. This favors the internalization in human osteosarcoma cells, where the release of topotecan takes place, drastically enhancing the cytotoxic effect.

Graphical abstract: Mesoporous silica nanoparticles engineered for ultrasound-induced uptake by cancer cells

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 Jan 2018, accepted on 26 Feb 2018 and first published on 27 Feb 2018


Article type: Paper
DOI: 10.1039/C8NR00693H
Citation: Nanoscale, 2018,10, 6402-6408
  •   Request permissions

    Mesoporous silica nanoparticles engineered for ultrasound-induced uptake by cancer cells

    J. L. Paris, M. Manzano, M. V. Cabañas and M. Vallet-Regí, Nanoscale, 2018, 10, 6402
    DOI: 10.1039/C8NR00693H

Search articles by author

Spotlight

Advertisements