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A universal strategy for one-pot synthesis of SERS tags


Surface-enhanced Raman scattering (SERS) tags have attracted tremendous interests in diverse fields owing to their outstanding sensitivity and multiplexing capability. However, the selection of Raman dyes that can be immobilized onto metal nanoparticles is very limited, because certain chemical groups are needed in the dye molecules to interact with the metal surface or through some intermediate layers. Here, we report a simple, rapid, and robust platform methodology for the one-pot preparation of Raman nanoprobes without the constraints of Raman dye chemical structures. We demonstrate this general approach by immobilizing dye molecules on silver nanoparticle surfaces that are difficult to incorporate previously, and show their applications in multiplexed immunohistochemistry (IHC). We expect this platform nanotechnology will significantly expand the library of SERS tags and their biomedical uses.

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Publication details

The article was received on 21 Jan 2018, accepted on 21 Mar 2018 and first published on 28 Mar 2018

Article type: Paper
DOI: 10.1039/C8NR00564H
Citation: Nanoscale, 2018, Accepted Manuscript
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    A universal strategy for one-pot synthesis of SERS tags

    J. Li, H. Liu, P. Rong, W. Zhou, X. Gao and D. Liu, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR00564H

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