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800 nm driven NaErF4@NaLuF4 upconversion platform for multimodality imaging and photodynamic therapy

Abstract

Multimodality imaging-guided therapy based on lanthanide-doped upconversion nanoparticles (UCNPs) has become a tendency in cancer theranostics. However, the overheating effect of 980 nm excitation in photodynamic therapy (PDT) and the difficulties in optimizing multimodality imaging integration within a single particle are still challenges. Herein, 800 nm driven NaErF4@NaLuF4 UCNPs have been explored for optimized multimodality imaging and NIR-triggered PDT. Our results confirmed that optimal ~5 nm shell thickness can well balance the enhancement of upconversion luminescence and the attenuation of energy transferred from Er3+ towards photosensitizer, to reach an efficient production of singlet oxygen (1O2) for PDT under 800 nm excitation. Furthermore, the as-obtained NaErF4@NaLuF4 UCNPs showed effective and applicable performance for upconversion luminescence (UCL) imaging, X-ray computed tomography (CT), and high-field T2 magnetic resonance imaging (MRI). This nanomaterial can serve as an excellent theranostic agent for multimodality imaging and image-guided therapy.

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Publication details

The article was received on 17 Jan 2018, accepted on 22 Mar 2018 and first published on 04 Apr 2018


Article type: Paper
DOI: 10.1039/C8NR00446C
Citation: Nanoscale, 2018, Accepted Manuscript
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    800 nm driven NaErF4@NaLuF4 upconversion platform for multimodality imaging and photodynamic therapy

    Q. Li, X. Li, L. Zhang, J. Zuo, Y. Zhang, X. Liu, T. Langping, B. Xue, Y. Chang and X. Kong, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR00446C

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