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Issue 14, 2018
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Room temperature synthesis of pH-switchable polyaniline quantum dots as a turn-on fluorescent probe for acidic biotarget labeling

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Abstract

The synthesis of well-defined light-element-derived quantum dots (LEQDs) with advanced optical properties under mild conditions is highly desirable yet challenging. Here, a polyaniline (PANI) structure is introduced into carbon-rich LEQDs to yield well-defined, fluorescent polyaniline quantum dots (PAQDs), PAQD24, through a one-pot room temperature reaction. The mild synthetic conditions effectively minimize the defects introduced during the conventional synthesis and endow PAQD24 with desirable optical properties, including a narrow emission band (full width at half maximum = 55 nm), an optimal quantum yield of 32.5% and two-photon fluorescence. Furthermore, the bandgap of PAQD24 is highly sensitive toward pH variations in the near-neutral region, due to the proton doping and dedoping of the PANI structure. Such unique properties together with its fine bio-compatibility enable the application of this material as a turn-on fluorescent probe for the labeling of acidic biotargets from sub-cellular to organ levels, providing potential applications in diagnosis and surgery guidance for certain diseases.

Graphical abstract: Room temperature synthesis of pH-switchable polyaniline quantum dots as a turn-on fluorescent probe for acidic biotarget labeling

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Publication details

The article was received on 15 Jan 2018, accepted on 25 Feb 2018 and first published on 05 Mar 2018


Article type: Paper
DOI: 10.1039/C8NR00381E
Citation: Nanoscale, 2018,10, 6660-6670
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    Room temperature synthesis of pH-switchable polyaniline quantum dots as a turn-on fluorescent probe for acidic biotarget labeling

    Y. Liu, Y. Ding, H. Gou, X. Huang, G. Zhang, Q. Zhang, Y. Liu, Z. Meng, K. Xi and X. Jia, Nanoscale, 2018, 10, 6660
    DOI: 10.1039/C8NR00381E

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