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Optosensing at the Nanobiointerface of Metal Ion-Optically-Active Nanocrystals

Abstract

Optically-active nanocrystals (such as quantum dots and plasmonic noble metal nanoparticles) have received great attention due to their size-tunable optical properties. Indicator displacement assay (IDA) with optically-active nanocrystals has become a common practice for optical sensor developments, since no sophisticated surface functionalization of nanoparticles is required. Among these IDA-based optical sensors, use of metal ions as receptors seems attractive. Therefore, in this review, the research progress of optical sensing at the nanobiointerface of metal ion-optically-active nanocrystals was summarized. Particularly, the metal ion-mediated selective recognition here was summarized based on the classical Hard-Soft-Acid-Base (HSAB) principle, which was seldom mentioned before. Most of the references were therefore categorized according to their located place in the HSAB theory. Besides, several metal ion modulation strategies that were not related to the HSAB theory (e.g., redox modulation) were also included. Finally, due to the cross-talk of metal ions in selective recognition, we also summarized the sensor array developments based on multiple metal ion receptors in IDA sensing with optically-active nanocrystals. Several interesting applications of the IDA sensing with metal ion as receptors and optically-active nanocrystals as indicators are presented, with specific emphasis on the design principles and photophysical mechanisms of these probes.

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Publication details

The article was accepted on 08 Feb 2018 and first published on 09 Feb 2018


Article type: Review Article
DOI: 10.1039/C8NR00350E
Citation: Nanoscale, 2018, Accepted Manuscript
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    Optosensing at the Nanobiointerface of Metal Ion-Optically-Active Nanocrystals

    H. Hu, H. He, J. Zhang, X. Hou and P. Wu, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR00350E

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