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A non-invasive nanoparticle mediated delivery of triamcinolone acetonide ameliorates diabetic retinopathy in rats


Diabetic retinopathy (DR) is a multifactorial manifestation associated with microvascular complications and is the fourth leading cause of visual impairment and blindness world-wide. Current day treatment of DR relies heavily on invasive techniques such as intravitreal injections of therapeutic agents. Unfortunately, intravitreal injections are associated with various complications such as intraocular bleeding, endophthalmitis, pain and discomfort resulting in poor patient compliance. Till date there is no non-invasive drug delivery system reported for DR treatment. To address this, we developed a core-shell nanoparticle-based delivery system consisting of a hydrophobic polycaprolactone core and hydrophilic pluronic® F68 shell, loaded with triamcinolone acetonide and evaluated its efficacy in a DR rat model. After treatment as eye drops, the drug loaded nanoparticles significantly improved structural (retinal thickness and vascular health) and functional activity (rod and cone function) of retina as compared to DR controls that were treated with drug alone or placebo nanoparticles. Further, drug loaded nanoparticles reduced retinal inflammation as evidenced by decrease in NF-κB, ICAM-1 and TNFα expression after 20 days of treatment. Similarly, a reduction in glial cell hyperplasia as evidenced by reduced GFAP expression, a decrease in microvascular complications as evidenced by decrease in VEGF secretion and microvascular tufts formation was observed in rat retinas after 40 days of treatment. The combined reduction in retinal inflammation and vascular abnormalities, both hall marks of DR, demonstrate the potential of the nanoparticulate delivery system for use as a topical formulation for treating DR.

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Publication details

The article was received on 03 Jan 2018, accepted on 22 Apr 2018 and first published on 04 May 2018

Article type: Paper
DOI: 10.1039/C8NR00058A
Citation: Nanoscale, 2018, Accepted Manuscript
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    A non-invasive nanoparticle mediated delivery of triamcinolone acetonide ameliorates diabetic retinopathy in rats

    B. Mahaling, D. A. Srinivasarao, G. Raghu, R. K. Kasam, G. B. Reddy and D. Katti, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR00058A

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