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Stable micelles based on a mixture of coiled-coils: the role of different oligomeric states

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Abstract

Homomeric micelles with tunable size, shape and stability have been extensively studied for biomedical applications such as drug carriers. However, designing the local valency and self-assembled morphology of nanophase-separated multicomponent micelles with varied ligand binding possibilities remains challenging. Here, we present micelles self-assembled from amphiphilic peptide–PEG–lipid hybrid conjugates, where the peptides can be either a 3-helix or 4-helix coiled-coil. We demonstrate that the micelle size and sphericity can be controlled based on the coiled-coil oligomeric state. Using theory and coarse-grained dissipative particle dynamics (DPD) simulations in an explicit solvent simulation, we studied the distribution of 3-helix and 4-helix conjugates within the mixed micelles and observed self-organization into nanodomains within the mixed micelle. We discovered that the phase separation behavior is dictated by the geometry mismatch in the alkyl chain length from different coiled-coil oligomeric states. Our analyses of the self-assembly tendency and drug delivery potency of mixed micelles with controlled multivalency provide important insights into the assembly and formation of nanophase-separated micelles.

Graphical abstract: Stable micelles based on a mixture of coiled-coils: the role of different oligomeric states

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Publication details

The article was received on 29 Dec 2017, accepted on 01 Mar 2018 and first published on 06 Mar 2018


Article type: Paper
DOI: 10.1039/C7NR09695J
Citation: Nanoscale, 2018, Advance Article
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    Stable micelles based on a mixture of coiled-coils: the role of different oligomeric states

    D. Ma and S. Keten, Nanoscale, 2018, Advance Article , DOI: 10.1039/C7NR09695J

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