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Issue 13, 2018
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Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates

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Abstract

In this study we used 5 nm gold nanoparticles as delivery platforms to target cancer cells expressing the immune receptor Tim-3 using single chain antibodies. Gold surfaces were also covered with the cytotoxic drug rapamycin which was immobilised using a glutathione linker. These nanoconjugates allowed highly specific and efficient delivery of cytotoxic rapamycin into human malignant blood cells.

Graphical abstract: Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates

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Publication details

The article was received on 19 Dec 2017, accepted on 02 Feb 2018 and first published on 14 Mar 2018


Article type: Communication
DOI: 10.1039/C7NR09436A
Citation: Nanoscale, 2018,10, 5827-5833
  • Open access: Creative Commons BY license
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    Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates

    I. M. Yasinska, G. Ceccone, I. Ojea-Jimenez, J. Ponti, R. Hussain, G. Siligardi, S. M. Berger, E. Fasler-Kan, M. Bardelli, L. Varani, W. Fiedler, J. Wellbrock, U. Raap, B. F. Gibbs, L. Calzolai and V. V. Sumbayev, Nanoscale, 2018, 10, 5827
    DOI: 10.1039/C7NR09436A

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