Jump to main content
Jump to site search

Issue 12, 2018
Previous Article Next Article

Secondary structure-induced aggregation by hydrogen peroxide: a stimuli-triggered open/close implementation by recombination

Author affiliations

Abstract

The fabrication of reactive aggregation nanomaterials through assemblies in a facile and cost-effective manner is much desired but remains to be well explored. Here we show that exquisite and ultra-long (>2 μm) hybrid polymer nanorods (NRs) can be formed by a simple self-assembly of a phenylboronic acid modified genistein crosslinker (Ge-di(HMPBA-pin)) and D-α-tocopheryl polyethylene glycol 1000 (TPGS). The obtained NRs exhibit quantitative and sensitive colorimetric detection of H2O2 with a remarkable detection limit for different stromal materials. More significantly, the presence of H2O2 triggers a distinct morphological transformation of the polymer NR assembly into the secondary structure of micelles via the oxidative deboronation of boronate moieties in HMPBA-pin-SA. It spontaneously induces the aggregation of metal nanoparticles (Au NPs), metal nanorods (Au NRs), quantum dots (MoS2 QDs), metal ions (Cu2+), protein (ferritin) and tetraphenylethene (TPE) molecules, giving rise to a dramatic stimuli-triggered open/close switchable complexation and apparent colorimetric transitions in vitro. This study, for the first time, showcases the fascinating advantages of such unprecedented secondary structure-induced aggregation and uncovers the immense potential to design a plethora of other sensing systems by virtue of the alternate trigger-specific, sacrifice-aggregated building moieties.

Graphical abstract: Secondary structure-induced aggregation by hydrogen peroxide: a stimuli-triggered open/close implementation by recombination

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Dec 2017, accepted on 11 Feb 2018 and first published on 13 Feb 2018


Article type: Paper
DOI: 10.1039/C7NR09356J
Citation: Nanoscale, 2018,10, 5503-5514
  •   Request permissions

    Secondary structure-induced aggregation by hydrogen peroxide: a stimuli-triggered open/close implementation by recombination

    G. Zhang, Q. Liao, Y. Liu, L. Wang, H. Gou, C. Ke, X. Huang, K. Xi and X. Jia, Nanoscale, 2018, 10, 5503
    DOI: 10.1039/C7NR09356J

Search articles by author

Spotlight

Advertisements