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Issue 10, 2018
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Boronic acid functionalized g-C3N4 nanosheets for ultrasensitive and selective sensing of glycoprotein in the physiological environment

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Abstract

As important biomarkers, glycoprotein sensing is frequently facilitated by boronic acid binding with its cis-diols. However, boronic acid based sensors suffer from drawbacks of alkali restriction and/or sensitivity limitation. Herein, we report boronic acid decorated g-C3N4 nanosheets (B-g-CN) with a Wulff-type boronic acid feature, which selectively bind glycoprotein under physiological conditions. Meanwhile, the binding causes significant enhancement of the B-g-CN nanosheet fluorescence, providing the basis for glycoprotein sensing. With IgG as a model, a detection limit (LOD) of 2.2 nM (3σ/s, n = 11) was obtained within a linear range of 6.7–67 nM. The LOD was further improved to 52 pM subject to enrichment of the nanosheets, which well enables IgG assay in human urine samples. Moreover, it was successful in imaging endogenous and exogenous glycoproteins in living cells.

Graphical abstract: Boronic acid functionalized g-C3N4 nanosheets for ultrasensitive and selective sensing of glycoprotein in the physiological environment

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Publication details

The article was received on 15 Dec 2017, accepted on 03 Feb 2018 and first published on 05 Feb 2018


Article type: Paper
DOI: 10.1039/C7NR09342J
Citation: Nanoscale, 2018,10, 4913-4920
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    Boronic acid functionalized g-C3N4 nanosheets for ultrasensitive and selective sensing of glycoprotein in the physiological environment

    Y. Wang, X. Hai, S. E, M. Chen, T. Yang and J. Wang, Nanoscale, 2018, 10, 4913
    DOI: 10.1039/C7NR09342J

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