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Se@SiO2-FA-CuS Nanocomposites for Targeted Delivery of DOX and Nano Selenium in Synergistic Combination of Chemo-photothermal Therapy

Abstract

In this work, a versatile tumor-targeted and multi-stimuli responsive drug delivery vehicle (Se particles@porous silica-folic acid-copper sulfide/doxorubicin (Se@SiO2-FA-CuS/DOX)) were fabricated for combined photothermal therapy with chemotherapy in cancer treatment. Due to excellent targeting ability the Se@SiO2-FA-CuS/DOX nanocomposites actively accumulated in tumor tissues, it provides photothermal therapy under NIR irradiation and chemotherapy through release of DOX and Se. Owing to the synergistic effect of chemotherapy (Se and DOX) and photothermal therapy, the Se@SiO2-FA-CuS/DOX nanocomposites could efficiently inhibit cancer cells both in vitro and in vivo, even completely eliminate the tumors. Moreover, as the toxicity of DOX could be reduced by Se, the treatment using Se@SiO2-FA-CuS/DOX nanocomposites exhibited no appreciable adverse reactions. Thus, the Se@SiO2-FA-CuS/DOX nanocomposites have great potential as a multifunctional nanoplatform in future clinical applications.

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Publication details

The article was accepted on 02 Jan 2018 and first published on 04 Jan 2018


Article type: Paper
DOI: 10.1039/C7NR09237G
Citation: Nanoscale, 2018, Accepted Manuscript
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    Se@SiO2-FA-CuS Nanocomposites for Targeted Delivery of DOX and Nano Selenium in Synergistic Combination of Chemo-photothermal Therapy

    Y. Wang, X. Liu, G. Deng, J. Sun, H. Yuan, Q. Li, Q. Wang and J. Lu, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C7NR09237G

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