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Polydiacetylenic nanofibers as new siRNA vehicles for in vitro and in vivo delivery

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Abstract

Polydiacetylenic nanofibers (PDA-Nfs) obtained by photopolymerization of surfactant 1 were optimized for intracellular delivery of small interfering RNAs (siRNAs). PDA-Nfs/siRNA complexes efficiently silenced the oncogene Lim-1 in the renal cancer cells 786-O in vitro. Intraperitoneal injection of PDA-Nfs/siLim1 downregulated Lim-1 in subcutaneous tumor xenografts obtained with 786-O cells in nude mice. Thus, PDA-Nfs represent an innovative system for in vivo delivery of siRNAs.

Graphical abstract: Polydiacetylenic nanofibers as new siRNA vehicles for in vitro and in vivo delivery

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Publication details

The article was received on 11 Dec 2017, accepted on 25 Dec 2017 and first published on 03 Jan 2018


Article type: Communication
DOI: 10.1039/C7NR09202D
Citation: Nanoscale, 2018, Advance Article
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    Polydiacetylenic nanofibers as new siRNA vehicles for in vitro and in vivo delivery

    P. Neuberg, I. Hamaidi, S. Danilin, M. Ripoll, V. Lindner, M. Nothisen, A. Wagner, A. Kichler, T. Massfelder and J.-S. Remy, Nanoscale, 2018, Advance Article , DOI: 10.1039/C7NR09202D

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