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3D printed scaffolds with gradient porosity based on a cellulose nanocrystal hydrogel

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Abstract

3-Dimensional (3D) printing provides a unique methodology for the customization of biomedical scaffolds with respect to size, shape, pore structure and pore orientation useful for tissue repair and regeneration. 3D printing was used to fabricate fully bio-based porous scaffolds of a double crosslinked interpenetrating polymer network (IPN) from a hydrogel ink of sodium alginate and gelatin (SA/G) reinforced with cellulose nanocrystals (CNCs). CNCs provided favorable rheological properties required for 3D printing. The 3D printed scaffolds were crosslinked sequentially via covalent and ionic reactions resulting in dimensionally stable hydrogel scaffolds with pore sizes of 80–2125 μm and nanoscaled pore wall roughness (visible from scanning electron microscopy) favorable for cell interaction. The 2D wide angle X-ray scattering studies showed that the nanocrystals orient preferably in the printing direction; the degree of orientation varied between 61–76%. The 3D printing pathways were optimised successfully to achieve 3-dimensional scaffolds (Z axis up to 20 mm) with uniform as well as gradient pore structures. This study demonstrates the potential of 3D printing in developing bio-based scaffolds with controlled pore sizes, gradient pore structures and alignment of nanocrystals for optimal tissue regeneration.

Graphical abstract: 3D printed scaffolds with gradient porosity based on a cellulose nanocrystal hydrogel

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Publication details

The article was received on 01 Dec 2017, accepted on 21 Jan 2018 and first published on 24 Jan 2018


Article type: Paper
DOI: 10.1039/C7NR08966J
Citation: Nanoscale, 2018, Advance Article
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    3D printed scaffolds with gradient porosity based on a cellulose nanocrystal hydrogel

    S. Sultan and A. P. Mathew, Nanoscale, 2018, Advance Article , DOI: 10.1039/C7NR08966J

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