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Nano-graphene oxide-manganese dioxide nanocomposites for overcoming tumor hypoxia and enhancing cancer radioisotope therapy

Abstract

While radiotherapy (RT) is commonly used in clinic for cancer treatment, the therapeutic efficiency is not satisfactory owing to the existence of the hypoxia tumor microenvironment which seriously affect the efficiency of RT. Herein, we design polyethylene glycol (PEG) modified reduced nano-graphene oxide-manganese dioxide (rGO-MnO2-PEG) nanocomposites to trigger oxygen generation from H2O2 to reduce the tumor hypoxic microenvironments. We use radioisotope, 131I labeled rGO-MnO2-PEG as therapeutic agents for in vivo tumor radioisotope therapy (RIT), achieving excellent tumor killing and further enhancing the therapeutic efficiency of RIT. More importantly, dissolution of MnO2 in acidic condition and the redox process during catalytic pathway of H2O2 decomposition in cellular microenvironment direct to the production of enormous amount of Mn2+ which has been used as contrast agents for magnetic resonance imaging (MRI). Our proposed work provides a novel strategy to trigger oxygen formation via internal stimulus to enhance imaging guided RIT efficiency.

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Publication details

The article was received on 23 Nov 2017, accepted on 31 Jan 2018 and first published on 01 Feb 2018


Article type: Paper
DOI: 10.1039/C7NR08747K
Citation: Nanoscale, 2018, Accepted Manuscript
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    Nano-graphene oxide-manganese dioxide nanocomposites for overcoming tumor hypoxia and enhancing cancer radioisotope therapy

    Y. Tao, L. Zhu, Y. Zhao, X. Yi, L. Zhu, F. Ge, X. Mou, L. Chen, L. Sun and K. Yang, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C7NR08747K

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