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Issue 8, 2018
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A scalable process to produce lipid-based compartmented Janus nanoparticles with pharmaceutically approved excipients

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Abstract

In the field of nanotechnologies, theranostic approaches and fixed-dose combination products require the development of innovative carriers able to co-encapsulate several entities of interest. This communication describes the preparation and characterization of lipid-based Janus compartmented nanoparticles. They were successfully prepared using a scalable process with pharmaceutically approved excipients. The analysis of the microscopic structure and supramolecular organization demonstrated the formation of two physico-chemically different compartments enabling the co-administration at once of both liposoluble and hydrosoluble active pharmaceutical ingredients.

Graphical abstract: A scalable process to produce lipid-based compartmented Janus nanoparticles with pharmaceutically approved excipients

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Publication details

The article was received on 14 Nov 2017, accepted on 26 Jan 2018 and first published on 26 Jan 2018


Article type: Communication
DOI: 10.1039/C7NR08488A
Citation: Nanoscale, 2018,10, 3654-3662
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    A scalable process to produce lipid-based compartmented Janus nanoparticles with pharmaceutically approved excipients

    T. Truong-Cong, E. Millart, L. T. C. Tran, H. Amenitsch, G. Frebourg, S. Lesieur and V. Faivre, Nanoscale, 2018, 10, 3654
    DOI: 10.1039/C7NR08488A

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