Jump to main content
Jump to site search

Issue 12, 2018
Previous Article Next Article

Two-photon graphene quantum dot modified Gd2O3 nanocomposites as a dual-mode MRI contrast agent and cell labelling agent

Author affiliations

Abstract

For obtaining high-resolution macroscopical anatomical information and high sensitivity microscopical optical signals, it is highly desirable to develop dual-modality magnetic resonance imaging (MRI) and fluorescent probes in medical imaging simultaneously. In this study, Gd2O3 nanoparticles were modified with two-photon graphene quantum dots (GQD), integrating a magnetic resonance imaging (MRI) contrast agent with two-photon imaging functionality into one nanoprobe. A photoluminescence study indicated that the GQD modification process integrated MRI properties with both one-photon and two-photon imaging properties. Gd2O3/GQD nanocomposites showed a significantly improved longitudinal relaxivity (r1 = 15.995 mM−1 s−1) in comparison with commercial Magnevist (Gd-DTPA, r1 = 4.5 mM−1 s−1) and some reported papers. Excellent water solubility and good biocompatibility make Gd2O3/GQD nanocomposites an ideal dual-modal imaging agent, suggesting their potential and significant biological and clinical applications in the future.

Graphical abstract: Two-photon graphene quantum dot modified Gd2O3 nanocomposites as a dual-mode MRI contrast agent and cell labelling agent

Back to tab navigation

Supplementary files

Publication details

The article was received on 30 Oct 2017, accepted on 11 Feb 2018 and first published on 16 Feb 2018


Article type: Paper
DOI: 10.1039/C7NR08068A
Citation: Nanoscale, 2018,10, 5642-5649
  •   Request permissions

    Two-photon graphene quantum dot modified Gd2O3 nanocomposites as a dual-mode MRI contrast agent and cell labelling agent

    F. H. Wang, K. Bae, Z. W. Huang and J. M. Xue, Nanoscale, 2018, 10, 5642
    DOI: 10.1039/C7NR08068A

Search articles by author

Spotlight

Advertisements