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Engineered contrast agents in a single structure for T1T2 dual magnetic resonance imaging

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The development of contrast agents (CAs) for Magnetic Resonance Imaging (MRI) with T1T2 dual-mode relaxivity requires the accurate assembly of T1 and T2 magnetic centers in a single structure. In this context, we have synthesized a novel hybrid material by monitoring the formation of Prussian Blue analogue Gd(H2O)4[Fe(CN)6] nanoparticles with tailored shape (from nanocrosses to nanorods) and size, and further protection with a thin and homogeneous silica coating through hydrolysis and polymerization of silicate at neutral pH. The resulting Gd(H2O)4[Fe(CN)6]@SiO2 magnetic nanoparticles are very stable in biological fluids. Interestingly, this combination of Gd and Fe magnetic centers closely packed in the crystalline network promotes a magnetic synergistic effect, which results in significant improvement of longitudinal relaxivity with regards to soluble Gd3+ chelates, whilst keeping the high transversal relaxivity inherent to the iron component. As a consequence, this material shows excellent activity as MRI CA, improving positive and negative contrasts in T1- and T2-weighted MR images, both in in vitro (e.g., phantom) and in vivo (e.g., Sprague-Dawley rats) models. In addition, this hybrid shows a high biosafety profile and has strong ability to incorporate organic molecules on the surface with variable functionality, displaying great potential for further clinical application.

Graphical abstract: Engineered contrast agents in a single structure for T1–T2 dual magnetic resonance imaging

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The article was received on 25 Oct 2017, accepted on 25 Feb 2018 and first published on 26 Feb 2018

Article type: Paper
DOI: 10.1039/C7NR07948F
Citation: Nanoscale, 2018, Advance Article
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    Engineered contrast agents in a single structure for T1T2 dual magnetic resonance imaging

    A. Cabrera-García, E. Checa-Chavarria, J. Pacheco-Torres, Á. Bernabeu-Sanz, A. Vidal-Moya, E. Rivero-Buceta, G. Sastre, E. Fernández and P. Botella, Nanoscale, 2018, Advance Article , DOI: 10.1039/C7NR07948F

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