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Issue 3, 2018
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Safe core-satellite magneto-plasmonic nanostructures for efficient targeting and photothermal treatment of tumor cells

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Abstract

Magneto-plasmonic nanostructures functionalized with cell targeting units are of great interest for nanobiotechnology applications. Photothermal treatment of cells targeted with antibody functionalized nanostructures and followed by magnetic isolation, allows killing selected cells and hence is one of the applications of great interest. The magneto-plasmonic nanostructures reported herein were synthesized using naked gold and magnetite nanoparticles obtained through a green approach based on laser ablation of bulk materials in water. These particles do not need purifications steps for biocompatibility and are functionalized with a SERRS (surface enhanced resonance Raman scattering) active molecule for detection and with an antibody for targeting prostate tumor cells. Quantitative results for the cell targeting and selection efficiency show an overall accuracy of 94% at picomolar concentrations. The photothermal treatment efficiently kills targeted and magneto-selected cells producing a viability below 5% after 3 min of irradiation, compared with almost 100% viability of incubated and irradiated, but non targeted cells.

Graphical abstract: Safe core-satellite magneto-plasmonic nanostructures for efficient targeting and photothermal treatment of tumor cells

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Publication details

The article was received on 21 Oct 2017, accepted on 06 Dec 2017 and first published on 06 Dec 2017


Article type: Paper
DOI: 10.1039/C7NR07844G
Citation: Nanoscale, 2018,10, 976-984
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    Safe core-satellite magneto-plasmonic nanostructures for efficient targeting and photothermal treatment of tumor cells

    F. Bertorelle, M. Pinto, R. Zappon, R. Pilot, L. Litti, S. Fiameni, G. Conti, M. Gobbo, G. Toffoli, M. Colombatti, G. Fracasso and M. Meneghetti, Nanoscale, 2018, 10, 976
    DOI: 10.1039/C7NR07844G

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