Jump to main content
Jump to site search


Compartmentalized supramolecular hydrogels based on viral nanocages towards sophisticated cargo administration

Author affiliations

Abstract

Introduction of compartments with defined spaces inside a hydrogel network brings unique features, such as cargo quantification, stabilization and diminishment of burst release, which are all desired for biomedical applications. As a proof of concept, guest-modified cowpea chlorotic mottle virus (CCMV) particles and complementary guest-modified hydroxylpropyl cellulose (HPC) were non-covalently cross-linked through the formation of ternary host–guest complexes with cucurbit[8]uril (CB[8]). Furthermore, CCMV based virus-like particles (VLPs) loaded with tetrasulfonated zinc phthalocyanine (ZnPc) were prepared, with a loading efficiency up to 99%, which are subsequently successfully integrated inside the supramolecular hydrogel network. It was shown that compartments provided by protein cages not only help to quantify the loaded ZnPc cargo, but also improve the water solubility of ZnPc to avoid undesired aggregation. Moreover, the VLPs together with ZnPc cargo can be released in a controlled way without an initial burst release. The photodynamic effect of ZnPc molecules was retained after encapsulation of capsid protein and release from the hydrogel. This line of research suggests a new approach for sophisticated drug administration in supramolecular hydrogels.

Graphical abstract: Compartmentalized supramolecular hydrogels based on viral nanocages towards sophisticated cargo administration

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 Oct 2017, accepted on 03 Dec 2017 and first published on 13 Feb 2018


Article type: Paper
DOI: 10.1039/C7NR07718A
Citation: Nanoscale, 2018, Advance Article
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    Compartmentalized supramolecular hydrogels based on viral nanocages towards sophisticated cargo administration

    L. Yang, A. Liu, M. V. de Ruiter, Catharina. A. Hommersom, N. Katsonis, P. Jonkheijm and J. J. L. M. Cornelissen, Nanoscale, 2018, Advance Article , DOI: 10.1039/C7NR07718A

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements