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Mixed-scale poly(methyl methacrylate) channel network-based single-particle manipulation via diffusiophoresis

Abstract

Despite the unique advantages of nanochannels imparted by their small size, their utility is limited by the lack of affordable and versatile fabrication methods. Moreover, nanochannel-incorporated fluidic devices require micro-sized conduit integration for efficient access of liquid samples. In this study, a simple and cost-effective fabrication method for mixed-scale channel networks via hot-embossing of poly(methyl methacrylate) (PMMA) using a carbon stamp is demonstrated. Due to its high rigidity, PMMA ensures collapse-free channel fabrication. The carbon stamp is fabricated using only batch microfabrication and has a convex architecture that allows the fabrication of a complex channel network via a single imprinting process. In addition, the microchannels are connected to nanochannels via three-dimensional (3D) microfunnels that serve as single-particle-entrapment chambers, ensuring smooth transport of samples into the nanochannels. Owing to the 3D geometry of the microfunnel and the small size of the nanochannels, a solute gradient can be generated locally at the microfunnel. This local solute gradient enables the entrapment of microparticles at the microfunnels via diffusiophoresis, which can manipulate particle motion in a controllable manner, without any external equipment or additional electrode integration into the channels. To the best of our knowledge, this is the first report of diffusiophoresis-based single-particle entrapment.

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Publication details

The article was received on 15 Oct 2017, accepted on 03 May 2018 and first published on 03 May 2018


Article type: Paper
DOI: 10.1039/C7NR07669J
Citation: Nanoscale, 2018, Accepted Manuscript
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    Mixed-scale poly(methyl methacrylate) channel network-based single-particle manipulation via diffusiophoresis

    J. Hong, B. Kim and H. Shin, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C7NR07669J

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