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Self-assembled thermoresponsive nanostructures of hyaluronic acid conjugates for osteoarthritis therapy

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Abstract

Under pathological conditions, joints and skin are often affected by an imbalance in the breakdown and production of hyaluronic acid (HA). The unique biochemical and biomechanical properties provided by HA must be restored for the long-term lubrication and cushioning effects. To overcome the inconvenience of repeated injections and the rapid degradation of exogenous HA treatments, HA is conjugated to a thermosensitive polymer, enabling the spontaneous formation of nanoparticles (HA Nano) at body temperature. Three HA Nano preparations are tested for their injectability, sensitivity to enzymatic degradation and cytocompatibility. One of them is delivered via subcutaneous and intra-articular injections to healthy mice and tested in a murine osteoarthritis (OA) model. It is found to be biocompatible, to offer a prolonged residence time at the injection site, have the ability to protect cartilage, to reduce pro-inflammatory cytokines and to preserve epiphysis thickness. In this study, HA Nano spontaneously forms nanoparticles at body temperature in vivo and is a promising candidate for the next generation of the sustainable/long-lasting treatment of OA and potentially also dermatological conditions.

Graphical abstract: Self-assembled thermoresponsive nanostructures of hyaluronic acid conjugates for osteoarthritis therapy

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Publication details

The article was received on 12 Oct 2017, accepted on 30 Nov 2017 and first published on 08 Dec 2017


Article type: Paper
DOI: 10.1039/C7NR07614B
Citation: Nanoscale, 2018, Advance Article
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    Self-assembled thermoresponsive nanostructures of hyaluronic acid conjugates for osteoarthritis therapy

    P. Maudens, S. Meyer, C. A. Seemayer, O. Jordan and E. Allémann, Nanoscale, 2018, Advance Article , DOI: 10.1039/C7NR07614B

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